Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach

• Published in: International journal of molecular sciences Vol. 22; no. 22; p. 12455
• Main Authors: Zughaibi, Torki A, Suhail, Mohd, Tarique, Mohammad, Tabrez, Shams
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18-11-2021; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; Akt; AKT protein; Antiinfectives and antibacterials; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - classification; Antineoplastic Agents, Phytogenic - pharmacology; Antioxidants; Antitumor activity; Antiviral activity; Antiviral agents; Biological properties; Cancer; Cell growth; Chemoprevention - methods; Chemotherapy; Drug resistance; Flavonoids; Flavonoids - chemistry; Flavonoids - classification; Flavonoids - pharmacology; Fruit - chemistry; Fruits; Gene Expression Regulation, Neoplastic; Humans; Inflammation; inhibitors; Kinases; mTOR; Mutation; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - prevention & control; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; PI3K; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Radiation therapy; Review; Side effects; Signal Transduction; TOR protein; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tumors; Vegetables - chemistry; mTOR; inhibitors; cancer; Akt; PI3K; flavonoids
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms222212455

Cancer is, globally, one of the main causes of death. Even though various therapies are available, they are still painful because of their adverse side effects. Available treatments frequently fail due to unpromising responses, resistance to classical anticancer drugs, radiation therapy, chemotherapy, and low accessibility to tumor tissues. Developing novel strategies to minimize adverse side effects, improve chemotherapy sensitivity, and control cancer progression is needed. Many studies have suggested small dietary molecules as complementary treatments for cancer patients. Different components of herbal/edible plants, known as flavonoids, have recently garnered attention due to their broad biological properties (e.g., antioxidant, antiviral, antimicrobial, anti-inflammatory, anti-mutagenic, anticancer, hepatoprotective, and cardioprotective). These flavonoids have shown anticancer activity by affecting different signaling cascades. This article summarizes the key progress made in this area and discusses the role of flavonoids by specifically inhibiting the PI3K/Akt/mTOR pathway in various cancers.