Transplantation of multipotent progenitors from the adult olfactory epithelium

Transplantation of multipotent progenitors from the adult olfactory epithelium

MAMMALIAN olfactory epithelium produces new neurons rapidly throughout adulthood. Here, we demonstrate that precursor cells harvested from the adult olfactory epithelium, when transplanted into the nasal mucosa of host rats exposed previously to an olfactotoxic gas, engraft and participate in neuroe...

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Bibliographic Details
Published in:Neuroreport Vol. 9; no. 7; pp. 1611 - 1617
Main Authors: Goldstein, Bradley J, Fang, Hengsheng, Youngentob, Steven L, Schwob, James E
Format: Journal Article
Language:English
Published: Hagerstown, MD Lippincott-Raven Publishers 11-05-1998
Lippincott Williams and Wilkins
Subjects:
Alkaline Phosphatase - biosynthesis
Animals
beta-Galactosidase - biosynthesis
Biological and medical sciences
Cell Differentiation
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Genetic Vectors
Humans
Mice
Moloney murine leukemia virus
Neurons - cytology
Neurons - physiology
Olfactory Bulb - physiology
Olfactory Mucosa - cytology
Olfactory Mucosa - physiology
Olfactory Mucosa - transplantation
Rats
Rats, Inbred F344
Recombinant Fusion Proteins - biosynthesis
Stem Cells
Transfection
Transplantation, Heterotopic
Vertebrates: nervous system and sense organs
Rat
Rodentia
Central nervous system
Transplantation
Olfactory system
Precursor
Regeneration
Vertebrata
Mammalia
Olfactory pathway
Olfactory bulb
Lesion
Olfactory epithelium
Brain (vertebrata)
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Summary:MAMMALIAN olfactory epithelium produces new neurons rapidly throughout adulthood. Here, we demonstrate that precursor cells harvested from the adult olfactory epithelium, when transplanted into the nasal mucosa of host rats exposed previously to an olfactotoxic gas, engraft and participate in neuroepithelial reconstitution. In contrast to their normal neuronal fate in situ, grafted precursors harvested from bulbectomized donors produced non-neuronal cells as well as neurons. These results demonstrate that epithelial precursors activated following olfactory bulbectomy are not irreversibly committed to making neurons. Thus, olfactory progenitors are subject to a form of feedback control in vivo that regulates the types of cells that they produce within a broader-than-neuronal repertoire.
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ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199805110-00065