Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs
Azomethine‐linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4‐oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1H‐NMR, 13C‐NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer c...
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| Published in: | Journal of heterocyclic chemistry Vol. 53; no. 6; pp. 1871 - 1877 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Blackwell Publishing Ltd
01-11-2016
Wiley Subscription Services, Inc |
| Online Access: | Get full text |
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| Summary: | Azomethine‐linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4‐oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1H‐NMR, 13C‐NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer cell lines (MDA‐AB‐231, BT‐474, and Ishikawa cells) revealed that the pyrrole–benzimidazole hybrids are more potent than the pyrazolone and 1,3,4‐oxadiazole hybrids in all cell lines. Compound 9 displayed promising cytotoxicity against BT‐474 cell line with IC50 values, 7.7 µM. |
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| Bibliography: | istex:4F4D6FC6A202C46744758945FED8C9948A980A28 ArticleID:JHET2501 ark:/67375/WNG-54DH0P2F-H ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0022-152X 1943-5193 |
| DOI: | 10.1002/jhet.2501 |