Direct lymphangiography as treatment option of lymphatic leakage: Indications, outcomes and role in patient's management

• Published in: European journal of radiology Vol. 83; no. 12; pp. 2167 - 2171
• Main Authors: Gruber-Rouh, Tatjana, Naguib, Nagy N.N, Lehnert, Thomas, Harth, Marc, Thalhammer, Axel, Beeres, Martin, Tsaur, Igor, Hammersting, Renate, Wichmann, Julian L, Vogl, Thomas J, Jacobi, Volkmar
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01-12-2014
• Subjects: Adult; Aged; Chylothorax - diagnostic imaging; Chylothorax - therapy; Chylous Ascites - diagnostic imaging; Chylous Ascites - therapy; Direct lymphangiography; Female; Fistula - diagnostic imaging; Fistula - therapy; Humans; Indications; Lymph; Lymphatic Diseases - diagnostic imaging; Lymphatic Diseases - therapy; Lymphocele - diagnostic imaging; Lymphocele - therapy; Lymphography; Male; Middle Aged; Outcomes; Radiology; Retrospective Studies; Role in patient's management; Treatment option of lymphatic leakage; Treatment Outcome; Indications; Direct lymphangiography; Outcomes; Role in patient's management; Treatment option of lymphatic leakage
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2014.09.013

Abstract Background To evaluate the effectiveness of lymphography as a minimally invasive treatment option of lymphatic leakage in terms of local control and to investigate which parameters influence the success rate. Method This retrospective study protocol was approved by the ethic committee. Patient history, imaging data, therapeutic options and follow-up were recorded and retrospectively analyzed. Between June 1998 and February 2013, 71 patients (m:w = 42:29, mean age, 52.4; range 42–75 years) with lymphatic leakage in form of lymphatic fistulas ( n = 37), lymphocele ( n = 11), chylothorax ( n = 13) and chylous ascites ( n = 10) underwent lymphography. Sixty-four patients (90.1%) underwent successful lymphography while lymphography failed in 7 cases. Therapeutic success was evaluated and correlated to the volume of lymphatic leakage and to the volume of the applied iodized oil. Result Signs of leakage or contrast extravasation were directly detected in 64 patients. Of 64 patients, 45 patients (70.3%) were treated and cured after lymphography. Based on the lymphography findings, 19 patients (29.7%) underwent surgical intervention with a completely occlusion of lymphatic leakage. The lymphatic leak could be completely occluded in 96.8% of patients when the lymphatic drainage volume was less than 200 mL/day ( n = 33). Even when lymphatic drainage was higher than 200 mL/day ( n = 31), therapeutic lymphography was still successful in 58.1% of the patients. Conclusion Lymphography is an effective, minimally invasive method in the detection and treatment of lymphatic leakage. The volume of lymphatic drainage per day is a significant predictor of the therapeutic success rate.