Considerations for the use of alloplastic temporomandibular joint replacement in irradiated patients: report of an off-label indication

• Published in: Journal of clinical medicine Vol. 12; no. 20; p. 6612
• Main Authors: Ângelo, David, Maffia, Francesco, Teschke, Marcus, Sanz, David, Galrito, Marta, Cardoso, Henrique, Marques, Rute, Nabuco, Carlos
• Format: Journal Article
• Language: English
• Published: Basel MDPI 01-10-2023; MDPI AG
• Subjects: Adjuvant radiotherapy; Asepsis; Cancer; Care and treatment; Clinical medicine; Contraindications; Debridement; Diagnosis; Dissection; Evaluation; Free tissue flaps; Head & neck cancer; Head and neck neoplasms; Health aspects; Infections; Joint replacement; Medical imaging; Methods; Mouth cancer; Off-label prescribing; Patients; Physiological aspects; Planning; Prostheses; Radiation therapy; Surgeons; Surgery; Temporomandibular joint; Titanium alloys; Total joint replacement; Portugal
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12206612

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Abstract: Background: Custom-made alloplastic temporomandibular joint replacement (ATMJR) is not validated in irradiated patients. However, in specific situations, after previous reconstructive surgical failures, the authors hypothesized the role of a customized ATMJR after radiotherapy. Methods: A 65-year-old male patient was referred to Instituto Português da Face—Lisbon, Portugal— after failed attempts of mandibular reconstruction secondary to oral carcinoma resection and partial hemi-mandibulectomy plus radiotherapy of 60 total Grays. Primary reconstruction was performed with fibula free flap. Due to failure, secondary reconstructions were performed with osteosynthesis plate without success. The patient was unable to have adequate mastication and deglutition due to a severe crossbite. The authors treated the patient with an extended customized alloplastic temporomandibular joint replacement (F0M2). Results: With 3 years of follow-up, the patient showed an improvement in masticatory function, mandibular motion, pain levels, and overall quality of life. No complications were observed related to ATMJR. Conclusions: The presented case described how ATMJR, although not a validated option after radiotherapy, can be considered to restore functionality in complex cases with bone and soft tissues problems.