Effects of Gold Nanoparticles Functionalized with Cornus mas L. Fruit Extract on the Aorta Wall in Rats with a High-Fat Diet and Experimental-Induced Diabetes Mellitus-An Imaging Study

• Published in: Nanomaterials (Basel, Switzerland) Vol. 13; no. 6; p. 1101
• Main Authors: Moldovan, Remus, Mitrea, Daniela-Rodica, Florea, Adrian, David, Luminiţa, Mureşan, Laura Elena, Chiş, Irina Camelia, Suciu, Şoimița Mihaela, Moldovan, Bianca Elena, Lenghel, Manuela, Chiriac, Liviu Bogdan, Ielciu, Irina, Hanganu, Daniela, Bab, Timea, Clichici, Simona
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19-03-2023; MDPI
• Subjects: Acids; Animals; antioxidants; Aorta; Bioactive compounds; Blood flow; Blood vessels; Carboxymethylcellulose; Cornus mas; Coronary vessels; Diabetes; Diabetes mellitus; Diet; Drug delivery; Drug delivery systems; endothelium; Experiments; Flow velocity; Fruits; Gold; gold nanoparticles; High fat diet; Hyperglycemia; Insulin; Magnetic resonance imaging; Nanoparticles; Oral administration; Pioglitazone; R&D; Research & development; Streptozocin; Transmission electron microscopy; Ultrasonic imaging; Bucharest Romania; Romania; United States > US; Germany; endothelium; aorta; antioxidants; gold nanoparticles; Cornus mas
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano13061101

Diabetes mellitus and high-fat diets trigger the mechanisms that alter the walls of blood vessels. Gold nanoparticles, as new pharmaceutical drug delivery systems, may be used in the treatment of different diseases. In our study, the aorta was investigated via imaging after the oral administration of gold nanoparticles functionalized with bioactive compounds derived from
fruit extract (AuNPsCM) in rats with a high-fat diet and diabetes mellitus. Sprague Dawley female rats that received a high-fat diet (HFD) for 8 months were injected with streptozotocin to develop diabetes mellitus (DM). The rats were randomly allocated into five groups and were treated, for one additional month with HFD, with carboxymethylcellulose (CMC), insulin, pioglitazone, AuNPsCM solution or with
L. extract solution. The aorta imaging investigation consisted of echography, magnetic resonance imaging and transmission electron microscopy (TEM). Compared to the rats that received only CMC, the oral administration of AuNPsCM produced significant increases in aorta volume and significant decreases in blood flow velocity, with ultrastructural disorganization of the aorta wall. The oral administration of AuNPsCM altered the aorta wall with effects on the blood flow.