Effect of three treatment protocols on acute ocular hypertension after phacoemulsification and aspiration of cataracts in dogs

• Published in: Veterinary ophthalmology Vol. 13; no. 1; pp. 14 - 19
• Main Authors: Crasta, Manuela, Clode, Alison B, McMullen Jr., Richard J, Pate, Diana O, Gilger, Brian C
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 2010; Blackwell Publishing Ltd
• Subjects: Administration, Topical; Animals; aspiration; carbachol; Carbachol - therapeutic use; cataract; Cataract Extraction - adverse effects; Cataract Extraction - veterinary; dog diseases; Dog Diseases - drug therapy; Dog Diseases - prevention & control; Dog Diseases - surgery; Dogs; inflammation; Intraocular Pressure - drug effects; IOP; latanoprost; ocular hypertension; Ocular Hypertension - etiology; Ocular Hypertension - prevention & control; Ocular Hypertension - veterinary; phacoemulsification; Phacoemulsification - adverse effects; Phacoemulsification - veterinary; postoperative complications; Postoperative Period; Prostaglandins F, Synthetic - therapeutic use; Retrospective Studies; surgery
• ISSN: 1463-5216; 1463-5224
• DOI: 10.1111/j.1463-5224.2009.00748.x

To compare the effect of topical latanoprost, intracameral carbachol, or no adjunctive medical therapy on the development of acute postoperative hypertension (POH) and inflammation after routine phacoemulsification and aspiration (PA) of cataracts in dogs. Retrospective study. Dogs received either one drop of topical 0.005% latanoprost (21 dogs, 39 eyes), an intracameral injection of 0.3 mL of 0.01% carbachol (15 dogs, 30 eyes), or no adjunctive therapy (46 dogs, 90 eyes) immediately following PA of cataract(s). Intraocular pressure (IOP) was measured in all dogs 2 and 4 h after surgery. IOP was measured and aqueous flare assessed at 8 am the day after surgery. Carbachol-treated dogs had significantly higher mean IOP (33.2 ± SD 20.8 mmHg) 2 h after surgery than dogs receiving no adjunctive therapy (22.0 ± SD 14.1 mmHg) (P = 0.049). There were no significant differences in IOP among groups at any other time point. There were no significant differences in number of POH episodes between dogs treated with carbachol (47%), latanoprost (29%), or dogs that received no adjunctive therapy (33%). There were no significant differences in mean aqueous flare grade between eyes treated with latanoprost (1.7 ± SD 0.4) or carbachol (1.4 ± SD 0.6), and eyes that received no adjunctive therapy (1.7 ± SD 0.4). Topical 0.005% latanoprost or intracameral injection of 0.3 mL of 0.01% carbachol after PA in dogs did not reduce POH or increase intraocular inflammation compared to dogs not receiving adjunctive therapy after PA of cataracts.