DNA Modified with Boron⁻Metal Cluster Complexes [M(C₂B₉H 11 )₂]-Synthesis, Properties, and Applications

• Published in: International journal of molecular sciences Vol. 19; no. 11; p. 3501
• Main Authors: Olejniczak, Agnieszka B, Nawrot, Barbara, Leśnikowski, Zbigniew J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07-11-2018; MDPI
• Subjects: Acids; Automation; Biosensors; Biotechnology; Boron; Boron - chemistry; boron clusters; Boron Compounds - chemical synthesis; Boron Compounds - chemistry; Chemical synthesis; Chemistry; Click Chemistry; Construction; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA probes; Incorporation; Ligands; Metal clusters; metallacarboranes; Molecular structure; Nucleic acids; oligonucleotide probes; Polymerase chain reaction; Review; therapeutic nucleic acids; metallacarboranes; therapeutic nucleic acids; boron clusters; DNA; oligonucleotide probes
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms19113501

Together with tremendous progress in biotechnology, nucleic acids, while retaining their status as "molecules of life", are becoming "molecular wires", materials for the construction of molecular structures at the junction between the biological and abiotic worlds. Herein, we present an overview of the approaches for incorporating metal centers into nucleic acids based on metal⁻boron cluster complexes (metallacarboranes) as the metal carriers. The methods are modular and versatile, allowing practical access to innovative metal-containing DNA for various applications, such as nucleic acid therapeutics, electrochemical biosensors, infrared-sensitive probes, and building blocks for nanoconstruction.