Superinfection exclusion studies using West Nile virus and Culex flavivirus strains from Argentina
In Argentina, many Flavivirus were recognised including West Nile virus (WNV). During 2009 several strains of Culex Flavivirus (CxFV), an insect-specific flavivirus, were isolated in the same region where circulation of WNV was detected. Hence, the objective of this study was to analyse the effect o...
Saved in:
| Published in: | Memórias do Instituto Oswaldo Cruz Vol. 115; p. e200012 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
01-01-2020
Fundação Oswaldo Cruz (FIOCRUZ) |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | In Argentina, many
Flavivirus
were recognised including West Nile virus (WNV). During 2009 several strains of Culex Flavivirus (CxFV), an insect-specific flavivirus, were isolated in the same region where circulation of WNV was detected. Hence, the objective of this study was to analyse the effect of co-infection
in vitro
assays using CxFV and WNV Argentinean strains in order to evaluate if CxFV could affect WNV replication. Our results showed that WNV replication was suppressed when multiplicity of infection (MOI) for CxFV was 10 or 100 times higher than WNV. Nevertheless,
in vivo
assays are necessary in order to evaluate the superinfection exclusion potential. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 SG, DE and SL conceived and designed the experiments; SG and EB performed the experiments; SG and JG analysed the data and interpreted results; SG wrote the manuscript; SL interpreted results and reviewed the paper. All authors reviewed and approved the final version. The authors declare no conflict of interest. |
| ISSN: | 0074-0276 1678-8060 1678-8060 |
| DOI: | 10.1590/0074-02760200012 |