A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp

• Published in: Toxicology letters Vol. 20; no. 2; p. 155
• Main Authors: Kawai, K, Kato, T, Mori, H, Kitamura, J, Nozawa, Y
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-1984
• Subjects: Animals; Anthraquinones - toxicity; Brain - drug effects; Brain - enzymology; Cells, Cultured; Cytotoxins; Emodin - toxicity; Microsomes - drug effects; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Oxidative Phosphorylation - drug effects; Rats; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
• ISSN: 0378-4274
• DOI: 10.1016/0378-4274(84)90141-3

The anthraquinone mycotoxins emodin and skyrin were examined for the inhibitory effects on murine leukemia L1210 culture cells, oxidative phosphorylation of rat liver mitochondria, and Na+, K+-activated ATPase activity of rat brain microsomes to find the differences between their modes of toxic action. Skyrin exhibited a stronger inhibitory effect than emodin on the growth of L1210 culture cells. Emodin showed a stronger uncoupling effect than skyrin on mitochondrial respiration. Skyrin inhibited Na+, K+-activated ATPase activity of rat brain microsomes but emodin did not inhibit.