Small ruminant lentivirus infections and diseases

• Published in: Veterinary microbiology Vol. 181; no. 1-2; pp. 75 - 89
• Main Authors: Minguijón, E., Reina, R., Pérez, M., Polledo, L., Villoria, M., Ramírez, H., Leginagoikoa, I., Badiola, J.J., García-Marín, J.F., de Andrés, D., Luján, L., Amorena, B., Juste, R.A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 14-12-2015
• Subjects: Animals; Caprine artritis encephalitis; Control; Diagnosis; Epidemiology; Goat Diseases - diagnosis; Goat Diseases - etiology; Goat Diseases - prevention & control; Goats; Host Specificity; Host-Pathogen Interactions; Lentivirus - genetics; Lentivirus - physiology; Lentivirus Infections - diagnosis; Lentivirus Infections - etiology; Lentivirus Infections - prevention & control; Lentivirus Infections - veterinary; Maedi; Pathogenesis; Ruminants - virology; Sheep; Sheep Diseases - diagnosis; Sheep Diseases - etiology; Sheep Diseases - prevention & control; Sheep, Domestic; Small ruminant lentivirus; SRLV; Visna; Control; Caprine artritis encephalitis; Pathogenesis; Diagnosis; Maedi; Small ruminant lentivirus; Epidemiology; Visna; SRLV
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/j.vetmic.2015.08.007

Small ruminant lentiviruses include viruses with diverse genotypes that frequently cross the species barrier between sheep and goats and that display a great genetic variability. These characteristics stress the need to consider the whole host range and to perform local surveillance of the viruses to opt for optimum diagnostic tests, in order to establish control programes. In the absence of effective vaccines, a comprehensive knowledge of the epidemiology of these infections is of major importance to limit their spread. This article intends to cover these aspects and to summarise information related to characteristics of the viruses, pathogenesis of the infection and description of the various syndromes produced, as well as the diagnostic tools available, the mechanisms involved in transmission of the pathogens and, finally, the control strategies that have been designed until now, with remarks on the drawbacks and the advantages of each one. We conclude that there are many variables influencing the expected cost and benefits of control programs that must be evaluated, in order to put into practice measures that might lead to control of these infections.