Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

• Published in: International journal of molecular sciences Vol. 22; no. 5; p. 2683
• Main Authors: Rodriguez, Princess D, Paculova, Hana, Kogut, Sophie, Heath, Jessica, Schjerven, Hilde, Frietze, Seth
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07-03-2021; MDPI
• Subjects: Acute lymphoblastic leukemia; B-cell; Biomarkers; Cancer therapies; Cell division; Chromosomes; Deoxyribonucleic acid; DNA; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genomes; Glucocorticoids - pharmacology; Homeostasis; Humans; Kinases; Leukemia; Lymphatic leukemia; Lymphocytes B; Medical prognosis; MicroRNAs; MicroRNAs - genetics; miRNA; Molecular modelling; non-coding; Non-coding RNA; Pathogenesis; Pediatrics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology; Proteins; Review; RNA polymerase; RNA, Long Noncoding - genetics; RNA, Untranslated - genetics; RNA-sequencing; small RNA-sequencing; Transcription factors; Transcriptomes; RNA-sequencing; leukemia; small RNA-sequencing; B-cell; non-coding
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22052683

Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell acute lymphoblastic leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.