The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs

• Published in: Drug delivery Vol. 13; no. 5; p. 351
• Main Authors: Staroverov, S A, Pristensky, D V, Yermilov, D N, Gabalov, K P, Zhemerichkin, D A, Sidorkin, V A, Shcherbakov, A A, Shchyogolev, S Yu, Dykman, L A
• Format: Journal Article
• Language: English
• Published: England 01-09-2006
• Subjects: Animals; Calcimycin - pharmacology; Cattle; Cells, Cultured; Diminazene - administration & dosage; Diminazene - analogs & derivatives; Diminazene - chemistry; Diminazene - pharmacokinetics; Dose-Response Relationship, Drug; Erythrocytes - cytology; Erythrocytes - metabolism; Injections, Intraperitoneal; Kidney - metabolism; Liposomes - chemistry; Liver - metabolism; Lymphocytes - metabolism; Macrophages - metabolism; Mice; Micelles; Solutions - chemistry; Tissue Distribution; Treatment Outcome; Trypanocidal Agents - administration & dosage; Trypanocidal Agents - chemistry; Trypanocidal Agents - pharmacokinetics; Water - chemistry
• ISSN: 1071-7544
• DOI: 10.1080/10717540500459084

The study was aimed at evaluating the effectiveness of liposomal, micellar, and water-soluble drug forms of diminazene for its localization in cells and selective accumulation at the sites of aggregation of pathogenic organisms. Pharmacological and dynamic properties of a new injection micellar diminazene preparation were experimentally determined. These properties were compared with the same parameters obtained for the water-soluble and liposomal diminazene aceturate drug forms. The drug forms studied may be arranged in the following order of decreasing effectiveness of accumulation of diminazene in red and white blood cells and in murine organs: liposome form, micellar form, and water-soluble form.