Exposing synonymous mutations

Highlights • Synonymous mutations, which do not result in a change in amino acid sequence, have been considered biologically silent. • Studies in molecular evolution show that synonymous codons are under selective pressure. • Synonymous mutation may affect the function of translated protein through...

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Bibliographic Details
Published in:	Trends in genetics Vol. 30; no. 7; pp. 308 - 321
Main Authors:	Hunt, Ryan C, Simhadri, Vijaya L, Iandoli, Matthew, Sauna, Zuben E, Kimchi-Sarfaty, Chava
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-07-2014
Subjects:	Animals Codon codon usage Computational Biology - methods Humans Medical Education mRNA structure Mutation Nucleic Acid Conformation Polymorphism, Single Nucleotide Protein Aggregation, Pathological - genetics Protein Biosynthesis Protein Conformation Protein Stability Protein Unfolding RNA Splicing RNA Stability RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism synonymous mutation synonymous single nucleotide polymorphism translation speed synonymous single nucleotide polymorphism codon usage synonymous mutation translation speed mRNA structure
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Summary:	Highlights • Synonymous mutations, which do not result in a change in amino acid sequence, have been considered biologically silent. • Studies in molecular evolution show that synonymous codons are under selective pressure. • Synonymous mutation may affect the function of translated protein through diverse cellular mechanisms. • Multiple methods should be applied to investigate synonymous variants and decipher the exact mechanisms by which they impact biological function.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0168-9525
DOI:	10.1016/j.tig.2014.04.006