A Review: Proteomics in Retinal Artery Occlusion, Retinal Vein Occlusion, Diabetic Retinopathy and Acquired Macular Disorders

• Published in: International journal of molecular sciences Vol. 18; no. 5; p. 907
• Main Authors: Cehofski, Lasse Jørgensen, Honoré, Bent, Vorum, Henrik
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28-04-2017; MDPI
• Subjects: Adhesion; Antibodies - immunology; Antibodies - therapeutic use; Carbonic anhydrase; Carbonic anhydrase I; Complement; Diabetes; Diabetes mellitus; Diabetic retinopathy; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - metabolism; Diabetic Retinopathy - pathology; Disease control; Epithelium; Extracellular matrix; Eye Proteins - metabolism; Humans; Macular degeneration; Macular Degeneration - drug therapy; Macular Degeneration - metabolism; Macular Degeneration - pathology; Nerve Growth Factors - metabolism; Occlusion; Pigment epithelium-derived factor; Proteome - analysis; Proteomics; Retina; Retinal Artery Occlusion - drug therapy; Retinal Artery Occlusion - metabolism; Retinal Artery Occlusion - pathology; Retinal Vein Occlusion - drug therapy; Retinal Vein Occlusion - metabolism; Retinal Vein Occlusion - pathology; Retinopathy; Review; Serpins - metabolism; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - immunology; Vascular Endothelial Growth Factor A - metabolism; biological marker; proteomics; retina; vascular endothelial growth factor; retinal vein occlusion; vitreous body; mass spectrometry; diabetic retinopathy; age-related macular degeneration
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms18050907

Retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR) and age-related macular degeneration (AMD) are frequent ocular diseases with potentially sight-threatening outcomes. In the present review we discuss major findings of proteomic studies of RAO, RVO, DR and AMD, including an overview of ocular proteome changes associated with anti-vascular endothelial growth factor (VEGF) treatments. Despite the severe outcomes of RAO, the proteome of the disease remains largely unstudied. There is also limited knowledge about the proteome of RVO, but proteomic studies suggest that RVO is associated with remodeling of the extracellular matrix and adhesion processes. Proteomic studies of DR have resulted in the identification of potential therapeutic targets such as carbonic anhydrase-I. Proliferative diabetic retinopathy is the most intensively studied stage of DR. Proteomic studies have established VEGF, pigment epithelium-derived factor (PEDF) and complement components as key factors associated with AMD. The aim of this review is to highlight the major milestones in proteomics in RAO, RVO, DR and AMD. Through large-scale protein analyses, proteomics is bringing new important insights into these complex pathological conditions.