Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms-The Risk of Malignant Tumors and Other Diseases

• Published in: International journal of molecular sciences Vol. 21; no. 21; p. 7822
• Main Authors: Rozmus, Dominika, Ciesielska, Alicja, Płomiński, Janusz, Grzybowski, Roman, Fiedorowicz, Ewa, Kordulewska, Natalia, Savelkoul, Huub, Kostyra, Elżbieta, Cieślińska, Anna
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22-10-2020; MDPI
• Subjects: Amino acids; Ankylosing spondylitis; Arthritis; Arthritis, Rheumatoid - genetics; Autoimmune diseases; Autoimmunity; Basal cell carcinoma; Binding sites; Bone turnover; Breast; Calciferol; Calcium homeostasis; Cancer; Cardiovascular disease; Cell cycle; Cholecalciferol - metabolism; Chronic obstructive pulmonary disease; Colorectal carcinoma; Coronary artery; Coronary Artery Disease - genetics; Diabetes mellitus; Diabetes Mellitus - genetics; Dietary supplements; Endocrine system; Ergocalciferols - metabolism; Female; Gene expression; Gene polymorphism; Genetic diversity; Genetic Predisposition to Disease; Genomes; Homeostasis; Humans; Immune system; Lung carcinoma; Lung diseases; Male; Melanoma; Metabolites; Mineralization; Neoplasms - genetics; Obesity - genetics; Pancreas; Polymorphism; Polymorphism, Single Nucleotide; Proteins; Pulmonary Disease, Chronic Obstructive - genetics; Radiation; Review; Rheumatoid arthritis; single nucleotide polymorphism; Skin; SNP; Thyroid; Tuberculosis; Tuberculosis - genetics; Tumors; VDBP; Vitamin D; vitamin D binding protein; Vitamin D-Binding Protein - genetics; Vitamin D-Binding Protein - physiology; SNP; VDBP; single nucleotide polymorphism; vitamin D; 25(OH)D; cancer; vitamin D binding protein
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21217822

Vitamin D is an important component of the endocrine system that controls calcium homeostasis and bone mineralization. Because of the very short half-life of free serum vitamin D it is stabilized and transported to target tissues by being bound to the vitamin D binding protein (VDBP). The most common polymorphisms: rs4588 and rs7041 in the vitamin D binding protein gene may correlate with differences in vitamin D status in the serum. This review presents data that relate to the presence of genetic variants in the VDBP gene in correlation with certain diseases, mostly concerning cancers (breast, prostate, pancreatic, lung, colorectal, basal cell carcinoma cancer and cutaneous melanoma) or other related diseases (thyroid autoimmunity disorders, obesity, diabetes mellitus, bone metabolism, rheumatoid arthritis, ankylosing spondylitis, asthma, chronic obstructive pulmonary disease, tuberculosis and coronary artery diseases).