Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: part II

• Published in: Arquivos de neuro-psiquiatria Vol. 80; no. 9; pp. 953 - 969
• Main Authors: Santos, Paulo Sergio Faro, Melhado, Eliana Meire, Kaup, Alexandre Ottoni, Costa, Aline Turbino Neves Martins da, Roesler, Célia Aparecida de Paula, Piovesan, Élcio Juliato, Sarmento, Elder Machado, Theotonio, Giselle Oliveira Martins, Campos, Henrique Carneiro de, Fortini, Ida, Souza, Jano Alves de, Júnior, Jayme Antunes Maciel, Segundo, João Batista Alves, Carvalho, João José Freitas de, Speziali, José Geraldo, Calia, Leandro Cortoni, Barea, Liselotte Menke, Queiroz, Luiz Paulo, Souza, Marcio Nattan Portes, Figueiredo, Marcos Ravi Cerqueira Ferreira, Costa, Maria Eduarda Nobre de Magalhães, Peres, Mário Fernando Prieto, Jurno, Mauro Eduardo, Peixoto, Patrícia Machado, Kowacs, Pedro André, Rocha-Filho, Pedro Augusto Sampaio, Filho, Pedro Ferreira Moreira, Silva-Neto, Raimundo Pereira, Fragoso, Yara Dadalti
• Format: Journal Article
• Language: English
• Published: Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Thieme Revinter Publicações Ltda 01-09-2022; Academia Brasileira de Neurologia - ABNEURO; Academia Brasileira de Neurologia (ABNEURO)
• Subjects: Brazil; Brazilian Academy of Neurology; Cefaleia Histamínica; Cluster Headache; Consenso; Consensus; Enxaqueca Sem Aura; Headache; Humans; Medicina Preventiva; Migraine Disorders - diagnosis; Migraine Disorders - drug therapy; Migraine Disorders - prevention & control; Migraine Without Aura; NEUROSCIENCES; Preventive Medicine; PSYCHIATRY; Venlafaxine Hydrochloride - therapeutic use; Brazil; Cluster Headache; Migraine Without Aura; Enxaqueca Sem Aura; Preventive Medicine; Cefaleia Histamínica; Medicina Preventiva; Consenso; Consensus
• ISSN: 0004-282X; 1678-4227; 1678-4227
• DOI: 10.1055/s-0042-1755320

Abstract
Background
 Migraine affects 1 billion people worldwide and > 30 million Brazilians; besides, it is an underdiagnosed and undertreated disorder.
Objective
 The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience.
Methods
 Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy.
Results
 From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease.
Conclusions
 Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options.