TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain

Highlights • We test behaviors between wild type and TRPV1 knockout febrile seizures mice. • Brain cytokines levels have been detected between wild type and TRPV1 knockout mice. • Expression levels of TRPV1 mRNA and protein increased in febrile seizures wild type mice. • Expression levels of IL-1β,...

Full description

Saved in:

Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 48; pp. 68 - 77
Main Authors:	Huang, Wen-Xian, Yu, Fang, Sanchez, Russell M, Liu, Yu-Qiang, Min, Jia-Wei, Hu, Jiang-Jian, Bsoul, Najeeb Bassam, Han, Song, Yin, Jun, Liu, Wan-Hong, He, Xiao-Hua, Peng, Bi-Wen
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-08-2015
Subjects:	Allergy and Immunology Animals Brain - immunology Brain - metabolism Cell Line Cytokines - metabolism Disease Models, Animal Febrile seizures Hippocampus - immunology Hippocampus - metabolism HMGB1 Hyperthermia, Induced IL-1β Mice Mice, Knockout Psychiatry Seizures, Febrile - immunology Seizures, Febrile - metabolism TRPV Cation Channels - genetics TRPV Cation Channels - metabolism TRPV1 Febrile seizures HMGB1 TRPV1 IL-1β
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Highlights • We test behaviors between wild type and TRPV1 knockout febrile seizures mice. • Brain cytokines levels have been detected between wild type and TRPV1 knockout mice. • Expression levels of TRPV1 mRNA and protein increased in febrile seizures wild type mice. • Expression levels of IL-1β, IL-6, TNF-α and HMGB1 increased in febrile seizures wild type mice. • Wild type mice are more susceptibility to febrile seizures than TRPV1 knockout mice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.01.017