Endonasal endoscopic nasopharyngectomy for nasopharyngeal malignancies: a survival analysis

• Published in: The Egyptian journal of otolaryngology Vol. 39; no. 1; pp. 171 - 6
• Main Authors: Iftikhar, Haissan, Awan, Muhammad Ozair, Ahmed, Shahzada Khuram
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2023; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Analysis; Cancer; Cancer therapies; Carotid arteries; Chemotherapy; Confidence intervals; Endoscopic nasopharyngectomy; Endoscopy; Females; Medicine; Medicine & Public Health; Nasopharyngeal carcinoma; Nasopharyngectomy; Original Article; Patient outcomes; Patients; Radiation; Radiation therapy; Radiotherapy; Skull base; Surgery; Surgical outcomes; Survival; Survival analysis; Throat cancer; United Kingdom; United Kingdom > UK; Nasopharyngeal carcinoma; Skull base; Endoscopic nasopharyngectomy; Nasopharyngectomy; Survival
• ISSN: 2090-8539; 1012-5574; 2090-8539
• DOI: 10.1186/s43163-023-00534-9

Introduction
Nasopharyngeal cancer has a global incidence of less than 1.0 per 100,000 person-years. It originates from nasopharyngeal mucosa with the Fossa of Rosenmuller being the most common site. Radiation therapy with or without chemotherapy is an established first-line treatment modality given the sensitivity of the tumor.
Objectives
The aim of our study was to report survival outcomes amongst patients undergoing endonasal endoscopic nasopharyngectomy at a tertiary care referral center.
Methods
We conducted a retrospective longitudinal cohort study. We collected data on age, gender, prior treatment, histology, extent of surgery, post-operative adjuvant therapy, and recurrence and reported the survival along mean survival time using Kaplan–Meier curves and log-rank test.
Results
A total of six patients, three males and three females with a mean age of 43.7 years were included in our study. Of the six, three patients underwent a salvage procedure whereas three patients received upfront definitive surgical resection. Three patients developed recurrence with a mean survival time of 19.3 months. The disease-free survival at 1 and 2 years of surgery was 88.3% and 66% respectively.
Conclusion
Endonasal endoscopic nasopharyngectomy is an effective surgical procedure that can be undertaken for both salvage and primary cases. Our survival results are comparable to the literature.