Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis

• Published in: Microorganisms (Basel) Vol. 9; no. 1; p. 14
• Main Authors: Ruddraraju, Kasi Viswanatharaju, Aggarwal, Devesh, Zhang, Zhong-Yin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 23-12-2020; MDPI AG
• Subjects: Mycobacterium tuberculosis (Mtb); pathogenic microorganisms; protein tyrosine phosphatases (PTPs); Review; signal transduction; tuberculosis (TB); virulence factors; PTP inhibitors; oxamic acids; salicylic acid derivatives; pathogenic microorganisms; protein tyrosine phosphatases (PTPs); signal transduction; Mycobacterium tuberculosis (Mtb); tuberculosis (TB); virulence factors
• ISSN: 2076-2607; 2076-2607
• DOI: 10.3390/microorganisms9010014

Tuberculosis (TB) is an airborne infectious disease caused by
(Mtb). According to the World Health Organization, an estimated 10 million people developed TB in 2018. The occurrence of drug-resistant TB demands therapeutic agents with novel mechanisms of action. Antivirulence is an alternative strategy that targets bacterial virulence factors instead of central growth pathways to treat disease.
protein tyrosine phosphatases, mPTPA and mPTPB, are secreted by Mtb into the cytoplasm of macrophages and are required for survival and growth of infection within the host. Here we present recent advances in understanding the roles of mPTPA and mPTPB in the pathogenesis of TB. We also focus on potent, selective, and well-characterized small molecule inhibitors reported in the last decade for mPTPA and mPTPB.