Central respiratory failure during acute organophosphate poisoning

Highlights • Organophosphate poisoning induces a central apnea that contributes to OP-induced respiratory failure. • Organophosphates induce apnea through a distributed effect on the brainstem circuitry involved in respiratory control. • Central efferent pathways contribute to pulmonary dysfunction...

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Bibliographic Details
Published in:	Respiratory physiology & neurobiology Vol. 189; no. 2; pp. 403 - 410
Main Authors:	Carey, Jennifer L, Dunn, Courtney, Gaspari, Romolo J
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-11-2013
Subjects:	Acute Disease Animals Central respiratory control Cholinergic neurons Humans Medical Education Nerve Net - drug effects Nerve Net - physiology Organophosphate Poisoning - complications Organophosphate Poisoning - diagnosis Organophosphate Poisoning - physiopathology Organophosphates Organophosphorus Compounds - toxicity Pre-Botzinger complex Pulmonary/Respiratory Respiratory Center - drug effects Respiratory Center - physiology Respiratory Insufficiency - complications Respiratory Insufficiency - diagnosis Respiratory Insufficiency - physiopathology Respiratory oscillators Respiratory oscillators Pre-Botzinger complex Central respiratory control Cholinergic neurons Organophosphates
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Summary:	Highlights • Organophosphate poisoning induces a central apnea that contributes to OP-induced respiratory failure. • Organophosphates induce apnea through a distributed effect on the brainstem circuitry involved in respiratory control. • Central efferent pathways contribute to pulmonary dysfunction following acute organophosphate poisoning.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2013.07.022