Clinical Significance of Long Intergenic Noncoding RNA-p21 in Colorectal Cancer

Micro-Abstract The impact of long intergenic noncoding RNA (lincRNA)-p21 on colorectal cancer (CRC) progression was investigated in this study. Wild-type p53 induces endogenous lincRNA-p21 in HCT-116 colon cancer cells. Elevated levels of lincRNA-p21 were significantly associated with CRC disease st...

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Bibliographic Details
Published in:	Clinical colorectal cancer Vol. 12; no. 4; pp. 261 - 266
Main Authors:	Zhai, Haiyan, Fesler, Andrew, Schee, Kristina, Fodstad, Øystein, Flatmark, Kjersti, Ju, Jingfang
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2013
Subjects:	Cell Line, Tumor Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease Progression Female Gastroenterology and Hepatology Hematology, Oncology and Palliative Medicine Humans lincRNA-p21 Male p53 Real-Time Polymerase Chain Reaction RNA, Long Noncoding - genetics lincRNA-p21 Colorectal cancer p53
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Summary:	Micro-Abstract The impact of long intergenic noncoding RNA (lincRNA)-p21 on colorectal cancer (CRC) progression was investigated in this study. Wild-type p53 induces endogenous lincRNA-p21 in HCT-116 colon cancer cells. Elevated levels of lincRNA-p21 were significantly associated with CRC disease state, pT, and vascular invasion, indicating that lincRNA-p21 may contribute to CRC progression.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1533-0028 1938-0674
DOI:	10.1016/j.clcc.2013.06.003