Goniotomy for Non-Infectious Uveitic Glaucoma in Children

• Published in: Journal of clinical medicine Vol. 12; no. 6; p. 2200
• Main Authors: Meerwijk, Charlotte L L I van, Edema, Astrid B, Rijn, Laurentius J van, Los, Leonoor I, Jansonius, Nomdo M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12-03-2023; MDPI
• Subjects: Care and treatment; Cataracts; Clinical medicine; Diagnosis; Edema; Failure; Glaucoma; Glaucoma in children; Independent sample; Intervention; Patient outcomes; Patients; Pediatrics; Services; Statistical analysis; Steroids; Surgery; Systemic diseases; Trabeculectomy; Visual acuity; Netherlands; childhood; uveitis; glaucoma; surgery
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12062200

Secondary glaucoma is still a blinding complication in childhood uveitis, for which most commonly used surgical interventions (trabeculectomy or glaucoma drainage implant) involve multiple re-interventions and/or complications postoperatively. The goniotomy procedure has never been investigated in the current era, in which patients with pediatric uveitis receive biologics as immunosuppressive therapy for a prolonged period, with potential implications for the outcome. The purpose of the study is to evaluate the efficacy and safety of a goniotomy procedure in pediatric non-infectious uveitis in a retrospective, multicenter case series. The primary outcomes were the postoperative intraocular pressure (IOP), number of IOP-lowering medications, and success rate. Postoperative success was defined as 6 ≤ IOP ≤ 21 mmHg, without major complications or re-interventions. Fifteen eyes of ten children were included. Median age of the included patients at goniotomy was 7 years; median follow-up was 59 months. Median (interquartile range) IOP before surgery was 30 (26-34) mmHg with 4 (3-4) IOP-lowering medications. At 1, 2, and 5 years after goniotomy, median IOP was 15, 14, and 15 mmHg with 2 (0-2), 1 (0-2), and 0 (0-2) medications, respectively (
< 0.001 postoperatively versus preoperatively for all timepoints). Success rate was 100%, 93%, and 80% after 1, 2, and 5 years, respectively. There were no significant changes in visual acuity and uveitis activity or its treatment, and there were no major complications. Our results show that the goniotomy is an effective and safe surgery for children with uveitic glaucoma.