Porous Organic Materials in Tissue Engineering: Recent Advances and Applications for Severed Facial Nerve Injury Repair

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 3; p. 566
• Main Authors: Sun, Jingxuan, Cao, Wenxin, Pan, Shuang, He, Lina, Ji, Dongchao, Zheng, Nannan, Sun, Xiangyu, Wang, Ranxu, Niu, Yumei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23-01-2024
• Subjects: Biocompatibility; Clinical medicine; facial nerve injury; facial nerve regeneration; Mechanical properties; nerve conduit; Permeability; Physiology; Porosity; Porous materials; porous organic materials; Tissue engineering; Transplants & implants; Trauma; Canada; nerve conduit; tissue engineering; facial nerve regeneration; facial nerve injury; porous organic materials
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29030566

The prevalence of facial nerve injury is substantial, and the restoration of its structure and function remains a significant challenge. Autologous nerve transplantation is a common treatment for severed facial nerve injury; however, it has great limitations. Therefore, there is an urgent need for clinical repair methods that can rival it. Tissue engineering nerve conduits are usually composed of scaffolds, cells and neurofactors. Tissue engineering is regarded as a promising method for facial nerve regeneration. Among different factors, the porous nerve conduit made of organic materials, which has high porosity and biocompatibility, plays an indispensable role. This review introduces facial nerve injury and the existing treatment methods and discusses the necessity of the application of porous nerve conduit. We focus on the application of porous organic polymer materials from production technology and material classification and summarize the necessity and research progress of these in repairing severed facial nerve injury, which is relatively rare in the existing articles. This review provides a theoretical basis for further research into and clinical interventions on facial nerve injury and has certain guiding significance for the development of new materials.