Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals

Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals

Vancomycin is a glycopeptide antibiotic employed in the treatment of infections caused by certain methicillin-resistant staphylococci. It is indicated also for patients allergic to penicillin or when there is no response to penicillins or cephalosporins. The adequate vancomycin concentration levels...

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Bibliographic Details
Published in:Química nova Vol. 30; no. 2; pp. 395 - 399
Main Authors: Vila, Marta Maria Duarte Carvalho, Oliveira, Robson Machado de, Gonçalves, Marcos Moisés, Tubino, Matthieu
Format: Journal Article
Language:English
Published: Sociedade Brasileira de Química 01-04-2007
Subjects:
antibiotic
quantitative analysis
vancomycin
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Summary:Vancomycin is a glycopeptide antibiotic employed in the treatment of infections caused by certain methicillin-resistant staphylococci. It is indicated also for patients allergic to penicillin or when there is no response to penicillins or cephalosporins. The adequate vancomycin concentration levels in blood serum lies between 5 and 10 mg/L. Higher values are toxic, causing mainly nephrotoxicity and ototoxicity. Various analytical methods are described in the literature: spectrophotometric, immunologic, biologic and chromatographic methods. This paper reviews the main analytical methods for vancomycin determination in biological fluids and in pharmaceutical preparations.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422007000200029