Traceable Self-Assembly of Laser-Triggered Cyanine-Based Micelle for Synergistic Therapeutic Effect

• Published in: Advanced healthcare materials Vol. 4; no. 6; pp. 892 - 902
• Main Authors: Chen, Yuan-I, Peng, Cheng-Liang, Lee, Pei-Chi, Tsai, Ming-Hsien, Lin, Chun-Yen, Shih, Ying-Hsia, Wei, Min-Feng, Luo, Tsai-Yueh, Shieh, Ming-Jium
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01-04-2015; Wiley Subscription Services, Inc
• Subjects: amphiphilic copolymers; Animals; Cancer; Carbocyanines - chemistry; Chemotherapy; Drug delivery systems; Glycols; Imaging; laser-triggered; Lasers; Medical research; Mice; Mice, Nude; Micelles; Nanostructure; NIR fluorescence imaging; photothermal-chemotherapy; Self assembly; amphiphilic copolymers; laser-triggered; micelles; NIR fluorescence imaging; photothermal-chemotherapy
• ISSN: 2192-2640; 2192-2659
• DOI: 10.1002/adhm.201400729

To track nanocarriers, many researches adopt nanocarriers labeled with radiotracers or encapsulating near‐infrared fluorescence (NIRF) dye. In this study, novel amphiphilic copolymers, methoxy poly(ethylene glycol) (mPEG)‐cyanine‐poly(ε‐caprolactone) (PCL) (mPEG‐Cy‐PCL) are synthesized. mPEG‐Cy‐PCL are capable of performing NIRF imaging, photothermal therapy (PTT) on cancer cells and self‐assembly nanocarriers. Cy‐based micelles can encapsulate doxorubicin (Doxo@Cy‐micelle) and achieve NIRF image‐guided drug delivery. Doxo@Cy‐micelles are nanosized micelles enhancing the accumulation of Doxo in tumor sites and decreasing side effects. Doxo@Cy‐micelles exhibit an excellent PTT and synergistic chemotherapy of cancer via laser‐triggered release of Doxo from micelles, eventually resulting in decreased cancer recurrence rates. The results show that Cy‐based micelles are excellent nanocarriers for NIRF imaging and synergistic photothermal‐chemotherapy of cancer.
Doxo@Cy‐micelle based on the novel amphiphilic copolymer, methoxy poly­(ethylene glycol) (mPEG)‐cyanine‐poly(ε‐caprolactone) (mPEG‐Cy‐PCL), is simultaneously used for tracking and NIRF image‐guided drug delivery. The obtained Doxo@Cy‐micelles exhibit the laser‐triggered release of Doxo and an excellent synergistic effect for the combined phototherapy and chemotherapy of cancer.