Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding

• Published in: Phytotherapy research Vol. 18; no. 12; pp. 1005 - 1007
• Main Authors: Jantan, I, Pisar, M, Sirat, H.M, Basar, N, Jamil, S, Ali, R.M, Jalil, J
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-12-2004; Wiley
• Subjects: Alpinia; Alpinia mutica; Animals; antagonistic activities; Biological and medical sciences; Blood Platelets - drug effects; Blood Platelets - physiology; Curcuma; Fruit; General pharmacology; Inhibitory Concentration 50; Kaempferia rotunda; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Platelet Activating Factor - antagonists & inhibitors; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - pharmacology; Platelet Aggregation Inhibitors - therapeutic use; platelet-activating factor (PAF); Rabbits; Rhizome; Zingiberaceae; antagonistic activities; Monocotyledones; Alpinia mutica; Pharmacognosy; Platelet activating factor; Medicinal plant; Curcuma xanthorrhiza; Angiospermae; Plant origin; platelet-activating factor (PAF); Spermatophyta; Curcuma; Kaempferia rotunda; Biological receptor; Zingiberaceae
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.1608

Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet‐activating factor (PAF) antagonistic activities on rabbit platelets using 3H‐PAF as a ligand. Among them, four compounds showed significant inhibitory effects. Alpinetin and 5,6‐dehydrokawain isolated from A. mutica exhibited IC50 values of 41.6 and 59.3 µm, respectively. The IC50 values of 3‐deacetylcrotepoxide and 2‐hydroxy‐4,4′,6′‐trimethoxychalcone from K. rotunda were 45.6 and 57.4 µM, respectively. 1‐Methoxy‐2‐methyl‐5‐(1′,5′‐dimethylhex‐4′‐enyl)‐benzene, synthesized by methylation of xanthorrhizol which was obtained from C. xanthorrhiza, showed an IC50 value of 40.9 µm. The results indicated that these compounds were relatively strong PAF receptor binding inhibitors. Copyright © 2004 John Wiley & Sons, Ltd.