Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia

• Published in: Neuroreport Vol. 19; no. 4; pp. 425 - 429
• Main Authors: Botta, Laura, Tritto, Simona, Perin, Paola, Laforenza, Umberto, Gastaldi, Giulia, Zampini, Valeria, Zucca, Gianpiero, Valli, Stefano, Masetto, Sergio, Valli, Paolo
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 05-03-2008; Lippincott Williams and Wilkins
• Subjects: Animals; Anura; Biological and medical sciences; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Fundamental and applied biological sciences. Psychology; Hair Cells, Ampulla - cytology; Hair Cells, Ampulla - metabolism; Histamine - metabolism; Immunoblotting; Immunohistochemistry; Medical sciences; Mice; Mice, Inbred C57BL; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Non tumoral diseases; Otorhinolaryngology. Stomatology; Rana esculenta; Receptors, Histamine H1 - genetics; Receptors, Histamine H1 - metabolism; Receptors, Histamine H3 - genetics; Receptors, Histamine H3 - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Semicircular Ducts - cytology; Semicircular Ducts - metabolism; Species Specificity; Vertebrates: nervous system and sense organs; Vertigo - drug therapy; Vertigo - metabolism; Vertigo - physiopathology; Vestibular Diseases - drug therapy; Vestibular Diseases - metabolism; Vestibular Diseases - physiopathology; Nervous system diseases; Frog; Rodentia; hair cell; Amphibia; Ciliated cell; Salientia; vestibular; Inner ear; Vertigo; Organ of hearing; Equilibrium disorder; Histamine; Vertebrata; Mammalia; Mouse; Animal; Semicircular canal; ENT disease; Vestibular system; H1 Histamine receptor
• ISSN: 0959-4965; 1473-558X
• DOI: 10.1097/WNR.0b013e3282f76151

Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine receptors in the frog and mouse semicircular canal sensory epithelia. Analysis was performed by mRNA reverse transcriptase-PCR, immunoblotting and immunocytochemistry experiments. Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found.