Ceria Nanoparticles that can Protect against Ischemic Stroke

• Published in: Angewandte Chemie International Edition Vol. 51; no. 44; pp. 11039 - 11043
• Main Authors: Kim, Chi Kyung, Kim, Taeho, Choi, In-Young, Soh, Min, Kim, Dohoung, Kim, Young-Ju, Jang, Hyunduk, Yang, Hye-Sung, Kim, Jun Yup, Park, Hong-Kyun, Park, Seung Pyo, Park, Sangseung, Yu, Taekyung, Yoon, Byung-Woo, Lee, Seung-Hoon, Hyeon, Taeghwan
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 29-10-2012; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Animals; apoptosis; Biomedical materials; Brain Ischemia - drug therapy; Brain Ischemia - metabolism; Brain Ischemia - prevention & control; Cell death; Cell Death - drug effects; Cell Survival - drug effects; ceria nanoparticles; Cerium - administration & dosage; Cerium - chemistry; Cerium - pharmacology; Cerium oxide; CHO Cells; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers - administration & dosage; Free Radical Scavengers - chemistry; Free Radical Scavengers - pharmacology; In vivo testing; In vivo tests; ischemic stroke; Metal Nanoparticles - administration & dosage; Metal Nanoparticles - chemistry; Nanoparticles; Rats; reactive oxygen species; Reactive Oxygen Species - metabolism; Scavenging; Stroke - drug therapy; Stroke - metabolism; Stroke - prevention & control; Strokes; therapeutic agents; Tissue Distribution
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201203780

Uniform 3 nm‐sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS‐induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.