Complete nucleotide sequence of the mouse lactate dehydrogenase-A functional gene: comparison of the exon-intron organization of dehydrogenase genes

• Published in: Genetics (Austin) Vol. 116; no. 1; pp. 99 - 105
• Main Authors: Fukasawa, Kayoko M, Li, Steven S.-L
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Genetics Soc America 01-05-1987; Genetics Society of America
• Subjects: Animals; Base Sequence; Biological and medical sciences; DNA Restriction Enzymes; Exons; Fundamental and applied biological sciences. Psychology; gene; Genes; Genes. Genome; genomas; genome; genomes; Humans; Introns; Investigations; L-Lactate Dehydrogenase - genetics; lactate dehydrogenase; lactate deshydrogenase; lactato deshidrogenasa; Mice; Mice, Inbred C57BL; Molecular and cellular biology; Molecular genetics; nucleotide; nucleotides; nucleotidos; Promoter Regions, Genetic; raton; Rats; Sequence Homology, Nucleic Acid; souris; Species Specificity; Vertebrata; Mammalia; Gene; Mouse; Nucleotide sequence; Enzyme; Rodentia; Lactate dehydrogenase; Gene organization
• ISSN: 0016-6731; 1943-2631; 1943-2631
• DOI: 10.1093/genetics/116.1.99

The complete sequence of 12,851 nucleotides of the mouse lactate dehydrogenase-A (LDH-A) gene has been determined. It includes eight exons, seven introns, promoter and regulatory regions. The B1 repetitive elements present in intron III and VI are oriented in opposite orientation, and they share 72% sequence homology. The exon-intron organization of mouse LDH-A gene is compared with the organizations of other dehydrogenase genes, and the molecular evolution of the nicotinamide adenine dinucleotide binding domains is discussed.