The DF-1 Chicken Fibroblast Cell Line: Transformation Induced by Diverse Oncogenes and Cell Death Resulting from Infection by Avian Leukosis Viruses

DF-1 is a continuous cell line of chicken embryo fibroblasts. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transfo...

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Bibliographic Details
Published in:	Virology (New York, N.Y.) Vol. 248; no. 2; pp. 295 - 304
Main Authors:	Himly, Martin, Foster, Douglas N., Bottoli, Ivan, Iacovoni, Jason S., Vogt, Peter K.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-09-1998
Subjects:	Animals Avian leukosis virus Avian Leukosis Virus - physiology Cell Death Cell Line - physiology Cell Line - virology Cell Transformation, Neoplastic Cells, Cultured Chick Embryo Chickens Fibroblasts - physiology Fibroblasts - virology Genes, jun - physiology Oncogenes - physiology Virus Replication
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Summary:	DF-1 is a continuous cell line of chicken embryo fibroblasts. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transformation on monolayers of DF-1, and avian leukosis viruses of envelope subgroups B, D, and C induce cell death and form plaques. The new cell line will greatly facilitate studies on oncogenic transformation and cell killing by avian viruses.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0042-6822 1096-0341
DOI:	10.1006/viro.1998.9290