Interplay of Oxidative Stress, Inflammation, and Autophagy: Their Role in Tissue Injury of the Heart, Liver, and Kidney

• Published in: Oxidative medicine and cellular longevity Vol. 2018; no. 1; p. 2090813
• Main Authors: Mukhopadhyay, Partha, Eid, Nabil, Abdelmegeed, Mohamed A., Sen, Aditya
• Format: Journal Article
• Language: English
• Published: United States Hindawi 01-01-2018; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Apoptosis; Autophagy; Biology; Diabetes; Disease; Free radicals; Heart; Humans; Inflammation; Ischemia; Kidney - injuries; Kidney - metabolism; Kidneys; Liver; Liver - injuries; Liver - metabolism; Medicine; Myocardium - metabolism; Oxidative Stress; Prevention; Rodents; Tissues
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2018/2090813

[...]upon exposure to chemicals or toxic agents such as alcohol, acetaminophen, and cisplatin, or under disease state such as diabetes, cancer, inflammatory diseases, and ischemia reperfusion, to name a few, ROS/RNS may be produced in excessive amounts, beyond the antioxidant cell defense capacity, from many sources within the cell such as cytochromes P450 2E1 and 4A, nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase), xanthine oxidase, and mitochondrial electron transport chain [3–5].Intriguingly, autophagy has been reported to regulate oxidative stress and inflammation signaling and formation [9].[...]it seems that there might be an interplay between oxidative stress, inflammation, and autophagy and that unchecked oxidative stress, unresolved inflammation, and disturbed autophagy are common features in many diseases, upon exposure to toxic chemicals, and even exposure to unhealthy dietary habits.[...]the last article presented the development of cardiac autonomic neuropathy (CAN) and the early signaling changes in the myocardium as early consequences of mild metabolic challenge without significant changes on gross cardiac structure/function and the absence of signs of diabetes or impaired glucose tolerance.[...]we would like to thank all the contributors to this special issue for their participation and interest and many others who submitted but we could not accommodate.