Analysis of risk factors for amputation in patients with diabetic foot ulcers: a cohort study from a tertiary center

• Published in: Acta orthopaedica et traumatologica turcica Vol. 56; no. 5; pp. 333 - 339
• Main Authors: Demirkol, Denizhan, Aktas, Samil, Ozcan, Tuncay, Selcukcan Erol, Cigdem, Tannier, Xavier
• Format: Journal Article
• Language: English
• Published: Ekin Medical Publishing 01-09-2022; Turkish Association of Orthopaedics and Traumatology, and Turkish Society of Orthopaedics and Traumatology; AVES
• Subjects: Computer Science; Endocrinology and metabolism; Human health and pathology; Life Sciences
• ISSN: 1017-995X; 2589-1294
• DOI: 10.5152/j.aott.2022.22052

Objective: This study aimed to analyze risk factors for amputation (overall, minor and major) in patients with diabetic foot ulcers (DFUs). Methods: 407 patients with DFUs (286 male, 121 female; mean age = 60, age range = 32-92) who were managed in a tertiary care centre from 2009 to 2019 were retrospectively identified and included in the study. DFUs were categorized based on the Meggit-Wagner, PEDIS, S(AD)SAD, and University of Texas (UT) classification systems. To identify amputation risk-related factors, results of patients with DFUs who underwent amputations (minor or major) were compared to those who received other adjunctive treatments using Chi-Square, oneway analysis of variance (ANOVA) and Spearman correlation analysis. Results: The mean C-reactive protein (CRP) and White Blood Cell (WBC) values were significantly higher in patients with major or minor amputation than in those without amputation. The mean Neutrophil (PNL), Platelets (PLT), wound width, creatinine and sedimentation (ESR) values were significantly higher in patients with major amputation compared to other groups of patients. Elevated levels of Highdensity lipoprotein (HDL), Hemoglobin (HGB) and albumin were determined to be protective factors against the risk of amputation. Spearman correlation analysis revealed a positive-sided, strong-levelled, significant relation between Wagner grades and amputation status of patients. Conclusion: This study has identified specific factors for major and minor amputation risk of patients with DFUs. Especially infection markers such as CRP, WBC, ESR and PNL were higher in the amputation group. Most importantly, Meggit Wagner, one of the four different classification