Transition‐Metal‐Catalyzed Three‐Component Difunctionalizations of Alkenes

• Published in: Chemistry, an Asian journal Vol. 13; no. 17; pp. 2277 - 2291
• Main Authors: Zhang, Ji‐Shu, Liu, Long, Chen, Tieqiao, Han, Li‐Biao
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 04-09-2018
• Subjects: Alkenes; Catalysis; Chemical reactions; Chemistry; difunctionalization; functionalized alkanes; multicomponent reactions; step-economic efficiency; multicomponent reactions; difunctionalization; step-economic efficiency; functionalized alkanes; alkenes
• ISSN: 1861-4728; 1861-471X
• DOI: 10.1002/asia.201800647

Three‐component reactions can directly convert three reactants into the desired products in one pot and thus greatly shorten the synthetic path. Recently, transition‐metal catalysis has been applied in the difunctionalization of alkenes and remarkable progress has been achieved to facilitate the construction of a wide range of functional molecules with high atom‐ and step‐economic efficiency. This Focus Review highlights recent advances in this field.
It takes three! Three‐component reactions can directly convert three reactants into products in one pot and thus greatly shorten the synthetic path (see figure). Recently, transition‐metal catalysis has been applied in the difunctionalization of alkenes and remarkable progress has been achieved to facilitate the construction of a wide range of functional molecules with high atom‐ and step‐economic efficiency. Recent advances in this field are highlighted.