Ruthenium‐Mediated Distal C−H Activation

• Published in: Chemistry, an Asian journal Vol. 13; no. 17; pp. 2243 - 2256
• Main Authors: Khan, Farheen Fatima, Sinha, Soumya Kumar, Lahiri, Goutam Kumar, Maiti, Debabrata
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 04-09-2018
• Subjects: Activation; Catalysis; Chemical industry; Chemistry; C−H activation; homogeneous catalysis; Organic chemistry; reaction mechanisms; regioselectivity; Ruthenium; ruthenium homogeneous catalysis meta regioselective para
• ISSN: 1861-4728; 1861-471X
• DOI: 10.1002/asia.201800545

Addressing remote C−H functionalization is a prominent challenge in the field of homogeneous catalysis. The past two decades have accounted for major developments in this domain, proclaiming efficient selectivity at the meta and para positions. Recognizing such transformations remains significant, owing to their importance in the biological and chemical industries. This focus review aims to summarize the relatively new concept of σ‐C−H activation enabled by a ruthenium metal center.
Active duty: Ruthenium‐mediated distal C−H activation has emerged as a promising alternative in recent decades. Both meta‐ and para‐selective products can be obtained with excellent selectivities by using this strategy. This review summarizes chronological developments in the field with mechanistic details.