A Direct Method for Site-Specific Protein Acetylation

Radicals at work: Radical‐mediated thiol‐ene addition of the thiol group of Cys to N‐vinylacetamide gives acetyl‐thialysine (KSAc), a near‐perfect mimic of acetyl‐lysine (see picture). The reaction is highly efficient with near quantitative conversion obtained in short reaction times. The generated...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 50; no. 41; pp. 9611 - 9614
Main Authors:	Li, Fupeng, Allahverdi, Abdollah, Yang, Renliang, Lua, Gavian Bing Jia, Zhang, Xiaohong, Cao, Yuan, Korolev, Nikolay, Nordenskiöld, Lars, Liu, Chuan-Fa
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 04-10-2011 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Acetylation Cysteine - chemistry epigenetics Histones - metabolism Molecular Structure posttranslational modifications protein modifications Protein Processing, Post-Translational Proteins - chemistry Proteins - genetics Proteins - metabolism radical reactions thiol-ene reactions
Online Access:	Get full text
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Summary:	Radicals at work: Radical‐mediated thiol‐ene addition of the thiol group of Cys to N‐vinylacetamide gives acetyl‐thialysine (KSAc), a near‐perfect mimic of acetyl‐lysine (see picture). The reaction is highly efficient with near quantitative conversion obtained in short reaction times. The generated KSAc is functionally identical or similar to its native counterpart.
Bibliography:	Ministry of Education AStar ArticleID:ANIE201103754 ark:/67375/WNG-4R1DTPQ0-6 istex:5B33918D8DE22BAE6409B448C6CCE996EBFA9F85 This work is supported by grants from AStar (C.F.L.) and Ministry of Education (L.N.) of Singapore. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201103754