Highly Selective Trifluoromethylation of 1,3-Disubstituted Arenes through Iridium-Catalyzed Arene Borylation

The old one two: A sequential iridium‐catalyzed borylation and copper‐catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. The advantages of this tandem procedure are de...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 51; no. 2; pp. 540 - 543
Main Authors:	Liu, Tianfei, Shao, Xinxin, Wu, Yaming, Shen, Qilong
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 09-01-2012 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Catalysis copper Copper - chemistry CH activation fluorine Fluorine Compounds - chemistry Halogenation homogeneous catalysis Hydrocarbons, Aromatic - chemistry iridium Iridium - chemistry Methylation
Online Access:	Get full text
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Summary:	The old one two: A sequential iridium‐catalyzed borylation and copper‐catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. The advantages of this tandem procedure are demonstrated by the late‐stage trifluoromethylation of a number of biologically active molecules.
Bibliography:	The authors thank Ms. Xiangqing Jia of the China Pharmaceutical University for conducting some experiments. We also thank the Key Program of the National Natural Science Foundation of China (21032006, 20632070), the National Natural Science Foundation of China (21172245), and the National Basic Research Program of China (2010CB126103, 2012CB821602) for financial support. National Basic Research Program of China - No. 2010CB126103; No. 2012CB821602 ark:/67375/WNG-96RSNKQ6-2 National Natural Science Foundation of China - No. 21032006; No. 20632070 National Natural Science Foundation of China - No. 21172245 istex:3FD160D5DDF490ADD831F2DC9734AA7BA32AD428 ArticleID:ANIE201106673 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201106673