Synthesis of Medium-Sized Rings by the Ring-Closing Metathesis Reaction
Conformational constraints are the keys for the efficient synthesis of medium‐sized rings by ring‐closing olefin metathesis (RCM). While the RCM reaction has already proved itself in the synthesis of the larger macrocycles, like that found in epothilone, only recently has this reaction been increasi...
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| Published in: | Angewandte Chemie International Edition Vol. 39; no. 12; pp. 2073 - 2077 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
Weinheim
WILEY-VCH Verlag GmbH
16-06-2000
WILEY‐VCH Verlag GmbH |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Conformational constraints are the keys for the efficient synthesis of medium‐sized rings by ring‐closing olefin metathesis (RCM). While the RCM reaction has already proved itself in the synthesis of the larger macrocycles, like that found in epothilone, only recently has this reaction been increasingly used in the construction of eight‐ to ten‐membered carbo‐ and heterocycles. In the picture, a cyclopentane ring ensures the conformational constraints necessary for a successful cyclization. |
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| Bibliography: | istex:292D9975116D8C7F840DCDFE630B8D58AAF65D5E ark:/67375/WNG-RVMMT42B-P ArticleID:ANIE2073 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1433-7851 1521-3773 |
| DOI: | 10.1002/1521-3773(20000616)39:12<2073::AID-ANIE2073>3.0.CO;2-0 |