Recent Advances in the Application of Selectfluor as a “Fluorine‐free” Functional Reagent in Organic Synthesis

• Published in: Chemistry, an Asian journal Vol. 15; no. 6; pp. 729 - 741
• Main Authors: Yang, Ke, Song, Mengjie, Ali, Ahmed I. M., Mudassir, Syed M., Ge, Haibo
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 16-03-2020
• Subjects: Chemical reactions; Chemistry; electrophilic fluorinating reagent; Fluorine; organic synthesis; Oxidizing agents; Reagents; Selectfluor; Transition metals; “fluorine-free” functional reagent; “fluorine-free” functional reagent; electrophilic fluorinating reagent; organic synthesis; Selectfluor
• ISSN: 1861-4728; 1861-471X
• DOI: 10.1002/asia.202000011

Selectfluor, [1‐chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo‐[2.2.2]octane bis(tetrafluoroborate)], is not only an important electrophilic fluorinating agent but also a facile and efficient “fluorine‐free” functional reagent in other organic reactions. In this Minireview, we will present a brief history of Selectfluor as a transition metal oxidant, fluorine cation and radical initiator in “fluorine‐free” functionalizations over the last five years.
Selectfluor as a “fluorine‐free” functional reagent in the application of various organic reactions as a transition‐metal oxidant, fluorine cation and radical initiator.