Statins can increase the risk of herpes zoster infection in Asia

• Published in: European journal of clinical microbiology & infectious diseases Vol. 34; no. 7; pp. 1451 - 1458
• Main Authors: Chen, H.-H., Lin, C.-L., Yeh, C.-J., Yeh, S.-Y., Kao, C.-H.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2015; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Asia - epidemiology; Biomedical and Life Sciences; Biomedicine; Codes; Cohort analysis; Cohort Studies; Comorbidity; Databases, Factual; Diabetes; Drug dosages; Female; Herpes viruses; Herpes Zoster - epidemiology; Herpes Zoster - etiology; Hospitals; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Incidence; Infections; Internal Medicine; Male; Medical Microbiology; Medicine; Middle Aged; National health insurance; Proportional Hazards Models; Regression analysis; Retrospective Studies; Risk; Statins; Young Adult; Asia; China; Taiwan; Propensity Score; Statin; Charlson Comorbidity Index; Statin Therapy; Herpes Zoster
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-015-2372-3

This study evaluated whether statin therapy increases the risk of herpes zoster (HZ) infection in Asia. This retrospective cohort study used the Longitudinal Health Insurance Database (LHID2000). From the LHID2000, patients aged 20 years were divided into two cohorts according to their statin use and were matched at a 1:1 ratio according to propensity scores, which were calculated using a logistic regression for estimating the probability of treatment assignment. The primary outcome was HZ infection. All patients were followed from the index date until the date of HZ infection, withdrawal from the insurance system, or the end of 2011. The study included 53,069 patients receiving statin therapy as a statin cohort and 53,069 patients without statin therapy as a nonstatin cohort. The mean follow-up durations for the statin cohort and nonstatin cohort were 4.89 [standard deviation (SD) = 2.86] years and 4.75 (SD = 2.90) years, respectively. The patients in the statin cohort had a 21 % higher risk of contracting HZ infection than the patients in the nonstatin cohort [95 % confidence interval (CI) = 1.13–1.29]. The incidence of HZ infection increased with the Charlson comorbidity index (CCI) score in both cohorts. A high mean defined daily dose of the six types of statins considered in this study was associated with a significantly increased risk of HZ infection. Statin therapy can increase HZ infection in Asia. More benefit–risk evaluations for statin use are necessary in Asia.