Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties

• Published in: Nanomaterials (Basel, Switzerland) Vol. 7; no. 10; p. 296
• Main Authors: Tanvir, Fouzia, Yaqub, Atif, Tanvir, Shazia, Anderson, William A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27-09-2017; MDPI
• Subjects: ">L-arginine; anti-bacterial; Anticancer properties; Antimicrobial activity; Antimicrobial agents; Arginine; Bacteria; E coli; Electron microscopy; Light scattering; Nanocomposites; Nanoparticles; Photon correlation spectroscopy; poly; Polyvinylpyrrolidone; Prisms; Pseudomonas aeruginosa; Salmonella; Silver; silver nanoparticles; Spectroscopy; stability; Transmission electron microscopy; Zeta potential; poly; anti-bacterial; silver nanoparticles; ">L-arginine; stability
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano7100296

The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by UV-visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta potential, as well as antimicrobial tests. These ultimately showed that a prismatic morphology exhibited stronger antimicrobial effects against
,
and
. The minimum bactericidal concentration was found to be 0.65 μg/mL in the case of a prismatic AgNP-poly-Arg-PVP (silver nanoparticle-poly-L-arginine-polyvinylpyrrolidone) nanocomposite. The anticancer cell activity of the silver nanoparticles was also studied, where the maximum effect against a HeLa cell line was 80% mortality with a prismatic AgNP-poly-Arg-PVP nanocomposite at a concentration of 11 μg/mL. The antimicrobial activity of these silver nanocomposites demonstrates the potential of such coated silver nanoparticles in the area of nano-medicine.