Serum Carboxy-Terminal Telopeptide of Type I Collagen (ICTP) Predicts Cardiac Events in Chronic Heart Failure Patients With Preserved Left Ventricular Systolic Function

• Published in: Circulation Journal Vol. 71; no. 6; pp. 929 - 935
• Main Authors: Kitahara, Tatsuro, Takeishi, Yasuchika, Arimoto, Takanori, Niizeki, Takeshi, Koyama, Yo, Sasaki, Toshiki, Suzuki, Satoshi, Nozaki, Naoki, Hirono, Osamu, Nitobe, Joji, Watanabe, Tetsu, Kubota, Isao
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2007
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Carboxy-terminal telopeptide of type I collagen (ICTP); Collagen Type I - blood; Diastolic HF; Female; Follow-Up Studies; Heart Failure - blood; Heart Failure - mortality; Humans; Male; Middle Aged; Peptides - blood; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Rate; Systole; Ventricular Function, Left
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.71.929

Background Clinical markers to predict adverse outcome have not yet been established for patients with preserved left ventricular (LV) systolic function. The present study was designed to examine whether carboxy-terminal telopeptide of type I collagen (ICTP), a marker of collagen degradation, is useful for determining the prognosis of such patients. Methods and Results Serum levels of ICTP were measured at admission in 156 consecutive patients hospitalized for chronic heart failure (CHF). Patients were divided into 2 groups based on the LV ejection fraction (LVEF): reduced LV systolic function group (LVEF <50%, n=92) and preserved LV systolic function group (LVEF ≥50%, n=64). In preserved LV systolic function group, cardiac event-free rates were significantly lower in high ICTP group than in low ICTP group (p<0.001). The area under the receiver operating characteristic curve of ICTP in the preserved LV systolic function group was markedly larger than that in the reduced LV systolic function group. Cox multivariate analysis also revealed that ICTP was an independent predictor of cardiac events in the preserved LV systolic function group. Conclusion Serum ICTP level is highly reliable for risk stratifying CHF patients with preserved LV systolic function. (Circ J 2007; 71: 929 - 935)