Early-childhood linear growth faltering in low- and middle-income countries

• Published in: Nature (London) Vol. 621; no. 7979; pp. 550 - 557
• Main Authors: Benjamin-Chung, Jade, Mertens, Andrew, Colford, John M., Hubbard, Alan E., van der Laan, Mark J., Coyle, Jeremy, Sofrygin, Oleg, Cai, Wilson, Nguyen, Anna, Pokpongkiat, Nolan N., Djajadi, Stephanie, Seth, Anmol, Jilek, Wendy, Jung, Esther, Chung, Esther O., Rosete, Sonali, Hejazi, Nima, Malenica, Ivana, Li, Haodong, Hafen, Ryan, Subramoney, Vishak, Häggström, Jonas, Norman, Thea, Brown, Kenneth H., Christian, Parul, Arnold, Benjamin F.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21-09-2023; Nature Publishing Group
• Subjects: 692/308/174; 692/308/3187; 692/699/1702/295; 706/134; Adult; Age; Asia, Southern - epidemiology; Child, Preschool; Children; Children & youth; Cognition; Cognitive ability; Cross-Sectional Studies; Developing Countries - statistics & numerical data; Developmental Disabilities - epidemiology; Developmental Disabilities - mortality; Developmental Disabilities - prevention & control; Female; Growth Disorders - epidemiology; Growth Disorders - mortality; Growth Disorders - prevention & control; Humanities and Social Sciences; Humans; Income; Infant; Infant, Newborn; Longitudinal Studies; Low income groups; Mortality; Mothers; multidisciplinary; Nutrition; Population; Prevention; Science; Science (multidisciplinary); Standard deviation; Trends; Asia, Southern; United States > US; Africa; Latin America; South Asia
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/s41586-023-06418-5

Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards)
1
,
2
. Stunting, a form of linear growth faltering, increases the risk of illness, impaired cognitive development and mortality. Global stunting estimates rely on cross-sectional surveys, which cannot provide direct information about the timing of onset or persistence of growth faltering—a key consideration for defining critical windows to deliver preventive interventions. Here we completed a pooled analysis of longitudinal studies in low- and middle-income countries (
n
 = 32 cohorts, 52,640 children, ages 0–24 months), allowing us to identify the typical age of onset of linear growth faltering and to investigate recurrent faltering in early life. The highest incidence of stunting onset occurred from birth to the age of 3 months, with substantially higher stunting at birth in South Asia. From 0 to 15 months, stunting reversal was rare; children who reversed their stunting status frequently relapsed, and relapse rates were substantially higher among children born stunted. Early onset and low reversal rates suggest that improving children’s linear growth will require life course interventions for women of childbearing age and a greater emphasis on interventions for children under 6 months of age.
A pooled analysis of longitudinal studies in low- and middle-income countries identifies the typical age of onset of linear growth faltering and investigates recurrent faltering in early life.