Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice

• Published in: NPJ science of food Vol. 4; no. 1; p. 7
• Main Authors: Tanaka, Mitsuru, Kiyohara, Hayato, Yoshino, Atsuko, Nakano, Akihiro, Takata, Fuyuko, Dohgu, Shinya, Kataoka, Yasufumi, Matsui, Toshiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-05-2020; Nature Publishing Group
• Subjects: 631/45/611; 692/700/2814; Amyloid; Blood-brain barrier; Brief Communication; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Food Microbiology; Food Science; Impairment; In vivo methods and tests; Latency; Nutrition; Oral administration; Spontaneous alternation
• ISSN: 2396-8370; 2396-8370
• DOI: 10.1038/s41538-020-0067-3

In this study, experiments on amyloid β peptide
25-35
-induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.