Robotic Versus Thoracoscopic Sub-lobar Resection for Octogenarians with Clinical Stage IA Non-small Cell Lung Cancer: A Propensity Score-Matched Real-World Study

• Published in: Annals of surgical oncology Vol. 31; no. 3; pp. 1568 - 1580
• Main Authors: Pan, Hanbo, Zou, Ningyuan, Tian, Yu, Shen, Yaofeng, Chen, Hang, Zhu, Hongda, Zhang, Jiaqi, Jin, Weiqiu, Gu, Zenan, Ning, Junwei, Jiang, Long, Huang, Jia, Luo, Qingquan
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-03-2024; Springer Nature B.V
• Subjects: Bleeding; Complications; Invasiveness; Lung cancer; Medicine; Medicine & Public Health; Non-small cell lung carcinoma; Oncology; Patients; Postoperative; Robotic surgery; Small cell lung carcinoma; Surgery; Surgical Oncology; Thoracic Oncology; Thoracic surgery; Sub-lobar resection; Lng-term outcomes; Octogenarians; Robotic-assisted thoracoscopic surgery; Video-assisted thoracoscopic surgery; Non-small cell lung cancer
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-023-14689-5

Background
Minimally invasive sub-lobectomy is sufficient in treating small early-stage non-small cell lung cancer (NSCLC). However, comparison of the feasibility and oncologic efficacy between robot-assisted thoracoscopic surgery (RATS) and video-assisted thoracoscopic surgery (VATS) in performing sub-lobectomy for early-stage NSCLC patients age 80 years or older is scarce.
Methods
Octogenarians with clinical stage IA NSCLC (tumor size, ≤ 2 cm) undergoing minimally invasive wedge resection or segmentectomy at Shanghai Chest Hospital from 2011 to 2020 were retrospectively reviewed from a prospectively maintained database. Propensity score-matching (PSM) with a RATS versus VATS ratio of 1:4 was performed. Perioperative and long-term outcomes were analyzed.
Results
The study identified 594 patients (48 RATS and 546 VATS patients), and PSM resulted in 45 cases in the RATS group and 180 cases in the VATS group. The RATS patients experienced less intraoperative bleeding (60 mL [interquartile range (IQR), 50–100 mL] vs. 80 mL [IQR, 50–100 mL];
P
= 0.027) and a shorter postoperative hospital stay (4 days [IQR, 3–5 days] vs. 5 days [IQR, 4–6 days];
P
= 0.041) than the VATS patients. The two surgical approaches were comparable concerning other perioperative outcomes and postoperative complications (20.00% vs. 26.11%;
P
= 0.396). Additionally, during a median follow-up period of 66 months, RATS and VATS achieved comparable 5-year overall survival (90.48% vs. 87.93%;
P
= 0.891), recurrence-free survival (83.37% vs. 83.18%;
P
= 0.782), and cumulative incidence of death. Further subgroup comparison also demonstrated comparable long-term outcomes between the two approaches. Finally, multivariate Cox analysis indicated that the surgical approach was not independently correlated with long-term outcomes.
Conclusions
The RATS approach shortened the postoperative hospital stay, reduced intraoperative bleeding by a statistically notable but clinically insignificant amount, and achieved long-term outcomes comparable with VATS in performing sub-lobectomy for octogenarians with early-stage small NSCLC.