Reconstructing fungal natural product biosynthetic pathways

Reconstructing fungal natural product biosynthetic pathways

Large scale fungal genome sequencing has revealed a multitude of potential natural product biosynthetic pathways that remain uncharted. Here we describe some of the methods that have been used to explore them via heterologous gene expression. We focus on filamentous fungal hosts and discuss the tech...

Full description

Saved in:
Bibliographic Details
Published in:Natural product reports Vol. 31; no. 10; p. 1339
Main Authors: Lazarus, C M, Williams, K, Bailey, A M
Format: Journal Article
Language:English
Published: England 01-10-2014
Subjects:
Biological Products - chemistry
Biological Products - metabolism
Biosynthetic Pathways
Fungi - chemistry
Fungi - metabolism
Genome, Fungal
Molecular Structure
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Large scale fungal genome sequencing has revealed a multitude of potential natural product biosynthetic pathways that remain uncharted. Here we describe some of the methods that have been used to explore them via heterologous gene expression. We focus on filamentous fungal hosts and discuss the technological challenges and successes behind the reconstruction of fungal natural product pathways. Optimised, efficient heterologous expression of reconstructed biosynthetic pathways promises progress in the discovery of novel compounds that could be utilised by the pharmaceutical and agrochemical industries.
ISSN:1460-4752
DOI:10.1039/c4np00084f