Curcuminoid Co-Loading Platinum Heparin-Poloxamer P403 Nanogel Increasing Effectiveness in Antitumor Activity

• Published in: Gels Vol. 8; no. 1; p. 59
• Main Authors: Nguyen, Ngoc The, Bui, Quynh Anh, Nguyen, Hoang Huong Nhu, Nguyen, Tien Thanh, Ly, Khanh Linh, Tran, Ha Le Bao, Doan, Vu Nguyen, Nhi, Tran Thi Yen, Nguyen, Ngoc Hoa, Nguyen, Ngoc Hao, Tran, Ngoc Quyen, Nguyen, Dinh Trung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14-01-2022; MDPI
• Subjects: Anticancer properties; Binding sites; Biocompatibility; Breast cancer; Cancer therapies; Drug delivery systems; Drugs; Efficiency; Heparin; In vivo methods and tests; Infrared spectroscopy; MCF-7; multi-drug delivery; nanogel; Nanoparticles; Necrosis; NMR spectroscopy; Particle size; poloxamer P403; Poloxamers; Polymers; Polyphenols; Side effects; Spectrum analysis; Synergistic effect; System effectiveness; heparin; multi-drug delivery; poloxamer P403; MCF-7; nanogel
• ISSN: 2310-2861; 2310-2861
• DOI: 10.3390/gels8010059

Nanosized multi-drug delivery systems provide synergistic effects between drugs and bioactive compounds, resulting in increased overall efficiency and restricted side effects compared to conventional single-drug chemotherapy. In this study, we develop an amphiphilic heparin-poloxamer P403 (HP403) nanogel that could effectively co-load curcuminoid (Cur) and cisplatin hydrate (CisOH) (HP403@CisOH@Cur) via two loading mechanisms. The HP403 nanogels and HP403@CisOH@Cur nanogels were closely analyzed with
H-NMR spectroscopy, FT-IR spectroscopy, TEM, and DLS, exhibiting high stability in spherical forms. In drug release profiles, accelerated behavior of Cur and CisOH at pH 5.5 compared with neutral pH was observed, suggesting effective delivery of the compounds in tumor sites. In vitro studies showed high antitumor activity of HP403@CisOH@Cur nanogels, while in vivo assays showed that the dual-drug platform prolonged the survival time of mice and prevented tail necrosis. In summary, HP403@CisOH@Cur offers an intriguing strategy to achieve the cisplatin and curcumin synergistic effect in a well-designed delivery platform that increases antitumor effectiveness and overcomes undesired consequences caused by cisplatin in breast cancer treatment.