Yellow fever vaccination – Once in a lifetime?

• Published in: Travel medicine and infectious disease Vol. 15; pp. 1 - 2
• Main Authors: Grobusch, Martin P, van Aalst, Mariëlle, Goorhuis, Abraham
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-01-2017; Elsevier Limited
• Subjects: Angola; Attitude towards vaccination; China; Conflicts of interest; Contraindications; Disease Outbreaks - prevention & control; Disease Outbreaks - statistics & numerical data; Fever; French Guiana; Funding; Humans; Immune-compromised; Immunization Schedule; Immunization, Secondary; Immunocompromised Host; Infectious Disease; Life-long immunity; Patients; Production capacity; Re-vaccination; Travel medicine; Vaccines; Vector-borne diseases; Viruses; WHO guidelines; Yellow Fever - epidemiology; Yellow Fever - immunology; Yellow Fever - prevention & control; Yellow fever vaccination; Yellow fever vaccination certificate; Yellow Fever Vaccine - administration & dosage; Yellow Fever Vaccine - immunology; Attitude towards vaccination; Yellow fever vaccination certificate; Life-long immunity; WHO guidelines; Immune-compromised; Re-vaccination; Yellow fever vaccination
• ISSN: 1477-8939; 1873-0442
• DOI: 10.1016/j.tmaid.2016.12.003

An additional and difficult problem in establishing the duration of protective immunity in various patient groups and at various vaccine doses is the lack of uniform, easy-to-use and affordable testing methods to measure post-vaccination immunity, which can be translated into robust and widely accepted correlates of protection. [...]more work needs to be done in order to come up with a convincing one-size-fits-it-all strategy (if possible at all), especially regarding the duration of protective immunity in response to one-time fractional dosing, and regarding the identification of suitable correlates of protection to reliably measure post YF vaccination immunity.