Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy

• Published in: European journal of dentistry Vol. 9; no. 1; pp. 60 - 65
• Main Authors: Erdemir, Ebru Olgun, Hendek, Meltem Karsiyaka, Keceli, H Gencay, Apan, Teoman Z
• Format: Journal Article
• Language: English
• Published: Germany Medknow Publications and Media Pvt. Ltd 01-01-2015; Medknow Publications & Media Pvt Ltd
• Subjects: Dental research; Interleukins; Original; Periodontitis; Physiological aspects; Europe; gingival crevicular fluid; interleukin-17; soluble intercellular adhesion molecule-1; Demineralized freeze-dried bone allograft; interleukin-8
• ISSN: 1305-7456; 1305-7464
• DOI: 10.4103/1305-7456.149644

The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP).
Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6(th) and the 9(th) month after the surgery.
Except plaque index, all clinical parameters improved following surgery (P < 0.05). The volume of GCF diminished from baseline to follow-up periods (P < 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF.
DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting.