Cancer immunotherapy: Pros, cons and beyond

• Published in: Biomedicine & pharmacotherapy Vol. 124; p. 109821
• Main Authors: Tan, Shuzhen, Li, Dongpei, Zhu, Xiao
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01-04-2020; Elsevier
• Subjects: Antineoplastic Agents, Immunological; Cancer immunotherapy; CAR-T; Drug Resistance - immunology; Humans; Immune checkpoint inhibitors; Immunotherapy - trends; Immunotherapy, Adoptive; Killer Cells, Natural; Neoplasms - therapy; PD-1; Tumor microenvironment; BiTE; TAPC; aeTSAs; MHC; BCMA; Cancer immunotherapy; KARs; KIRs; PFS; MM; RECIST; CIK; imRECIST; NKC; CAF; Immune checkpoint inhibitors; LTSCP; iUPD; CAR-T; MAK; hTERT; irAE; CyTOF; HPD; MSI-H; PD-1; TGR; CRS; ICIs; DAMPs; TAMs; mTSAs; ADCC; APCs; MSI; OS; Tumor microenvironment; Tregs; ACI; TMB; bTMB; TME; MDSCs; PD; TCR-T; TAA; TIL; LAK; CTL; ITH; DC
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2020.109821

•Tumor immunotherapy mainly includes ICIs, cellular immunotherapy, exosome immunotherapy, and other novel therapies.•The therapeutic effect of immunotherapy is affected by immune microenvironment, intestinal bacteria and TMB.•Drug resistance and adverse reactions are challenges in the development of immunotherapy.•The future direction of immunotherapy is mainly to reduce side effects and improve the targeting of therapy.
Cancer immunotherapy is an innovative treatment for tumors today. In various experiments and clinical studies, it has been found that immunotherapy does have incomparable advantages over traditional anti-tumor therapy, which can prolong progression-free survival (PFS) and overall survival (OS). However, immunotherapy has obvious complexity and uncertainty. Immunotherapy may also cause severe adverse reactions due to an overactive immune system. More effective and fewer adverse reactions immunological checkpoints are still under further exploration. This review gives an overview of recent developments in immunotherapy and indicates a new direction of tumor treatment through analyzing the pros and cons of immunotherapy coupled with keeping a close watch on the development trend of the immunotherapy future.